HEPATOPROTECTIVE EFFECTS OF AQUEOUS AND METHANOLIC LEAVES EXTRACTS OF AZADIRACTA INDICA AGAINST CARBON TETRACHLORIDE (CCL4) INDUCED HEPATOTOXICITY IN WISTAR RATS

Authors

  • Sunday G.A. Department of Biological Sciences, Nigerian Defence Academy, Kaduna
  • Dr Dikwa K.B Depatrment of Biological Sciences, Nigerian Defence Academy, Kaduna, Nigeria
  • Alhaji A.I. Department of Biotechnology, Nigerian Defence Academy, Kaduna
  • Vantsawa P.A. Department of Biological Sciences, Nigerian Defence Academy, Kaduna
  • Nwankwo C.T. Department of Biotechnology, Nigerian Defence Academy, Kaduna
  • Muazu Muhammed Pharmacology Laboratory, College of Health Sciences, Kogi State University, Anyigba, Nigeria

Keywords:

Azadiracta indica, Hepatoprotective, Hepatotoxicity, CCL4-induced, Leaves extracts

Abstract

Abstract

The hepatoprotective effects of aqueous and methanolic leaf extracts of Azadirachta indica on carbon tetrachloride (CCl4) induced liver damage was determined in this study. Hepatoprotective effects of aqueous and methanolic leaf extracts of A. indica were determined by evaluating the liver function enzymes namely; Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total bilirubin (T. bil) and Alkaline phosphatase (ALP). Results showed weight gain in groups (I, III, IV, V, VI, and VII) and weight loss in group II. Significant (p < 0.05) increased in levels of AST, ALT, ALP, and T.BIL in CCl4-intoxicated rats were restored through normalization in aqueous and methanolic extracts’ treated rats in a dose-dependent manner. The aqueous extracts (150mg/kg body weight), methanolic leaf extracts (150mg/kg body weight) and silymarin (100mg/kg) showed potential hepatoprotective effects with a significant decrease (p < 0.05). The study suggests that aqueous and methanolic leaf treatments of A. indica has shown to be a potentially good human hepatoprotective medicinal plant at a higher dose of 150mg/kg body weight.

Key words: Azadiracta indica, Hepatoprotective, Hepatotoxicity, Induced, Leaves extracts

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Author Biography

Dr Dikwa K.B, Depatrment of Biological Sciences, Nigerian Defence Academy, Kaduna, Nigeria

She started her career as graduate assistant in 1997 and rose to the rank of Associate Professor of Microbiology (Medical parasitology) in 2021. Depatrment of Biological Sciences, Nigerian Defence Academy, Kaduna, Nigeria. She is currently the Departmental PG Coordinator. A Member of Nigerian Society for Microbiology (NSM), Parasitology and Public Health Society of Nigeria (PPSN) and Zoological Society of Nigeria (ZSN).

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Published

2024-04-30

How to Cite

Sunday G.A., Dikwa K.B, Alhaji A.I., Vantsawa P.A., Nwankwo C.T., & Muhammed, M. (2024). HEPATOPROTECTIVE EFFECTS OF AQUEOUS AND METHANOLIC LEAVES EXTRACTS OF AZADIRACTA INDICA AGAINST CARBON TETRACHLORIDE (CCL4) INDUCED HEPATOTOXICITY IN WISTAR RATS. Academy Journal of Science and Engineering, 18(1), 100–107. Retrieved from https://ajse.academyjsekad.edu.ng/index.php/new-ajse/article/view/370

Issue

Vol. 18 No. 1 (2024): Academy Journal of Science and Engineering (AJSE)

Section

Articles

License

Copyright (c) 2024 Sunday G.A., Dr Dikwa K.B, Alhaji A.I., Vantsawa P.A., Nwankwo C.T., Muazu Muhammed

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